| Aug. 31 | Old Dominion | 19 | South Carolina | 23 | SECN | 4:15 PM |
| Aug. 31 | Southern Miss | 0 | Kentucky | 31 | SECN | 7:45 PM |
| Sep. 1 | Southern California | 27 | LSU | 20 | ABC | 7:30 PM |
| Sep. 7 | South Carolina | 31 | Kentucky | 6 | ABC | 3:30 PM |
| Sep. 7 | South Florida | 16 | Alabama | 42 | ESPN | 7:00 PM |
| Sep. 14 | LSU | 36 | South Carolina | 33 | ABC | Noon |
| Sep. 21 | Akron | 7 | South Carolina | 50 | TBA | TBA |
| Sep. 28 | South Alabama | 10 | LSU | 42 | SECN | 7:45 PM |
| Oct. 5 | Ole Miss | 27 | South Carolina | 3 | TBA | TBA |
| Oct. 12 | South Carolina | 25 | Alabama | 27 | ABC | 9:00 AM |
| Oct. 19 | South Carolina | 35 | Oklahoma | 9 | ABC | 9:45 AM |
| Nov. 2 | Texas A&M | 20 | South Carolina | 44 | ABC | 7:30 PM |
| Nov. 9 | South Carolina | 28 | Vanderbilt | 7 | SEC | 4:15 PM |
| Nov. 16 | Missouri | 30 | South Carolina | 34 | SEC | 4:15 PM |
| Nov. 23 | Wofford | 12 | South Carolina | 56 | ESPN+ | 4:00 PM |
| Nov. 30 | South Carolina | 17 | Clemson | 14 | ESPN | Noon |
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